HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-1-Benzoyl-3-methylpiperazine → 1-[(2R)-4-benzoyl-2-methyl-piperazin-1-yl]-2-(7-chloro-1H-pyrrolo[3,2-b]pyridin-3-yl)ethane-1,2-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-1-Benzoyl-3-methylpiperazine | HCID 7578227 | — |
| Reactant | Potassium (7-chloro-4-azaindol-3-yl)-oxoacetate | HCID 22893818 | — |
| Product | 1-[(2R)-4-benzoyl-2-methyl-piperazin-1-yl]-2-(7-chloro-1H-pyrrolo[3,2-b]pyridin-3-yl)ethane-1,2-dione | HCID 5495829 | — |
Reaction Steps
Precursor 5d, 1-benzoyl-3-(R)-methyl-4-[(7-chloro-4-azaindol-3-yl)-oxoacetyl]piperazine was prepared by the same method as Precursor 5a, starting from Potassium (7-chloro-4-azaindol-3-yl)-oxoacetate, Precursor 4e, and 1-benzoyl-3-(R)-methyl piperazine. MS m/z: (M+H)+ calcd for C21H20ClN4O3 411.12, found 411.04. HPLC retention time: 1.10 minutes (column A).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07501420B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-366bc8e54aa84a60b04042c260ce0c55 |
| Source note | uspto-grants-2009_03 |