(R)-1-Benzoyl-3-methylpiperazine → HCID 59693973, compound

HRID 1783573Notes

Reaction equation

HRID 1783573 reaction equation
[K+].[Br:2][C:3]1[N:4]=[CH:5][CH:6]=[C:7]2[C:11]=1[NH:10][CH:9]=[C:8]2[C:12](=[O:16])[C:13]([O-:15])=O.[C:17]([N:25]1[CH2:30][CH2:29][NH:28][C@H:27]([CH3:31])[CH2:26]1)(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[C:17]([N:25]1[CH2:30][CH2:29][N:28]([C:13](=[O:15])[C:12]([C:8]2[C:7]3[C:11](=[C:3]([Br:2])[N:4]=[CH:5][CH:6]=3)[NH:10][CH:9]=2)=[O:16])[C@H:27]([CH3:31])[CH2:26]1)(=[O:24])[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

3

Reactant 2

HCID 7578227(R)-1-Benzoyl-3-methylpiperazineHCID 59693965HCID 59693965, compound

Product 1

HCID 59693973HCID 59693973, compound

Procedure

Precursor 5f, 1-benzoyl-3-(R)-methyl-4-[(7-bromo-6-azaindol-3-yl)-oxoacetyl]piperazine was prepared by the same method as Precursor 5a, starting from (7-bromo-6-azaindol-3-yl)-oxoacetic acid potassium salt, Precursor 4g, and 1-benzoyl-3-(R)-methylpiperazine. MS m/z: (M+H)+ calcd for C21H20BrN4O3: 455.07; found 455.14. HPLC retention time: 1.45 minutes (column B).

Sources & evidence

ORD record
ord-52687537d26442759399f73147a374df
Source dataset
uspto-grants-2009_03
Patent number
US07501420B2

Reaction notes

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