(R)-1-Benzoyl-3-methylpiperazine → HCID 507783, compound

HRID 1783575Notes

Reaction equation

HRID 1783575 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[N:7][CH:8]=2)[C:3]([C:10](=[O:14])[C:11]([O-:13])=O)=[CH:2]1.[K+].[C:16]([N:24]1[CH2:29][CH2:28][NH:27][C@H:26]([CH3:30])[CH2:25]1)(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[C:16]([N:24]1[CH2:29][CH2:28][N:27]([C:11](=[O:13])[C:10]([C:3]2[C:4]3[C:9](=[CH:8][N:7]=[CH:6][CH:5]=3)[NH:1][CH:2]=2)=[O:14])[C@H:26]([CH3:30])[CH2:25]1)(=[O:23])[C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 7578227(R)-1-Benzoyl-3-methylpiperazineHCID 22893814HCID 22893814, compound

Product 1

HCID 507783HCID 507783, compound

Procedure

Precursor 5h, 1-benzoyl-3-(R)-methyl-4-[(6-azaindol-3-yl)-oxoacetyl]piperazine was prepared by the same method as Precursor 5a starting from Potassium (6-azaindol-3-yl)oxoacetate, Precursor 4b, and 1-benzoyl-3-(R)-methylpiperazine. MS m/z: (M+H)+ Calc'd for C21H21N4O3: 377.16; Found 377.10. HPLC retention time: 0.88 minutes (column A).

Sources & evidence

ORD record
ord-cf037c06287b432c9c835d8afecd9068
Source dataset
uspto-grants-2009_03
Patent number
US07501420B2

Reaction notes

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