HCID 59693965, compound → HCID 59693890, compound

HRID 1783580Notes

Reaction equation

HRID 1783580 reaction equation
[Br:1][C:2]1[N:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][CH:8]=[C:7]2[C:11](=[O:15])[C:12]([O-:14])=O.[K+].[CH3:17][C@@H:18]1[NH:23][CH2:22][CH2:21][N:20]([C:24](=[O:31])[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][N:26]=2)[CH2:19]1>>[N:26]1[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=1[C:24]([N:20]1[CH2:21][CH2:22][N:23]([C:12](=[O:14])[C:11]([C:7]2[C:6]3[C:10](=[C:2]([Br:1])[N:3]=[CH:4][CH:5]=3)[NH:9][CH:8]=2)=[O:15])[C@@H:18]([CH3:17])[CH2:19]1)=[O:31]

Participants

3

Reactant 2

HCID 59693965HCID 59693965, compoundHCID 67152700HCID 67152700, compound

Product 1

HCID 59693890HCID 59693890, compound

Procedure

Precursor 5n, (S)-1-picolinoyl-3-methyl-4-[(7-bromo-6-azaindol-3-yl)-oxoacetyl]piperazine was prepared by the same method as Precursor 5a starting from Potassium (7-bromo-6-azaindol-3-yl)oxoacetate, Precursor 4g, and (S)-3-methyl-1-picolinoyl-piperazine. 1H NMR (500 MHz, CDCl3) δ 8.63-7.36 (m, 7H), 5.02-3.06 (m, 7H), 1.42-1.26 (m, 3H).

Sources & evidence

ORD record
ord-1eb79520a9784ba1af23dffd3379eb93
Source dataset
uspto-grants-2009_03
Patent number
US07501420B2

Reaction notes

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