Acetonitrile → HCID 5280190, compound

HRID 1783591Notes

Reaction equation

HRID 1783591 reaction equation
[C:1]([N:9]1[CH2:14][CH2:13][N:12]([C:15](=[O:36])[C:16]([C:18]2[C:26]3[C:21](=[C:22]([CH:29]4[CH:33]=[CH:32][C:31](=[C:34]=[O:35])[O:30]4)[N:23]=[CH:24][C:25]=3[O:27][CH3:28])[NH:20][CH:19]=2)=[O:17])[CH2:11][CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O-:37]Cl=O.[Na+].CC#N>O>[C:1]([N:9]1[CH2:10][CH2:11][N:12]([C:15](=[O:36])[C:16]([C:18]2[C:26]3[C:21](=[C:22]([C:29]4[O:30][C:31]([C:34]([OH:37])=[O:35])=[CH:32][CH:33]=4)[N:23]=[CH:24][C:25]=3[O:27][CH3:28])[NH:20][CH:19]=2)=[O:17])[CH2:13][CH2:14]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 6342AcetonitrileHCID 23668197Sodium ChloriteHCID 87288404HCID 87288404, compound

Product 1

HCID 5280190HCID 5280190, compoundYield 25.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of the compound of Example 85 (19 mg), NaClO2 (9.2 mg) in a mixed solution of CH3CN (3 mL) and water (0.5 mL) was stirred at room temperature for 24 hours. After the reaction was quenched by 1N NaOH solution (1 ml), the mixture was extracted with diethyl ether (3×10 mL). The aqueous phase was acidified with 1N HCl to give a yellow solid precipitate (5 mg) which was the product shown. MS m/z: (M+H)+ Calc'd for C26H23N6O7: 503.16; found 503.19. HPLC retention time: 1.37 minutes (column A).

Workup

  1. customAfter the reaction was quenched by 1N NaOH solution (1 ml)
  2. extractionthe mixture was extracted with diethyl ether (3×10 mL)

Sources & evidence

ORD record
ord-e28dee11518e4e9d97105c288d70e3e4
Source dataset
uspto-grants-2009_03
Patent number
US07501420B2

Reaction notes

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