Trifluoroacetic acid → HCID 57838300, compound

Participants

Reaction Conditions

Reaction Steps

(S)-(2-{4-[3-Chloro-4-(3-fluoro-phenoxymethyl)-phenylamino]-quinazolin-6-ylimino-}-3-methyl-oxazolidin-4-yl)-methanol is prepared from (S)-N6-(4-tert-butoxymethyl-3-methyl-oxazolidin-2-ylidene)-N4-[3-chloro-4-(3-fluoro-phenoxymethyl)-phenyl-]quinazoline-4,6-diamine. TFA (1 ml) is added to (S)-N6-(4-tert-butoxymethyl-3-methyl-oxazolidin-2-ylidene)-N4-[3-chloro-4-(3-fluoro-phenoxymethyl)-phenyl-]-quinazoline-4,6-diamine (0.104 g, 0.184 mmol) in 1 ml methylene chloride at 0° C. After stirring for 2 hours at 0° C. and 3 hours at room temperature, the reaction mixture is diluted with 1,2-dichloroethane and concentrated. The residue is diluted with methylene chloride and washed with 10% Na2CO3. The aqueous layer is extracted with methylene chloride, and the combined organic extracts dried (Na2SO4) and concentrated to give 60 mg (64%) pure desired product. MS ESI (+) m/z 508, 510 (M+1, Cl pattern) detected; 1H NMR (400 MHz, CDCl3) δ 8.7 (s, 1 H), 8.1 (s, 1 H), 7.8-7.4 (m, 6 H), 7.2 (m, 1 H), 6.8-6.7 (m, 3 H), 5.1 (s, 2 H), 4.5 (m, 2 H), 4.0 (dd, 1 H, J=13, 3.9 Hz), 3.9 (m, 1 H), 3.8 (br d, 1 H, J=13.0 Hz), 3.1 (s, 3 H).

Provenance & Evidence