HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → Aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 2-((2-Chloro-4-nitrophenoxy)methyl)thiazole | HCID 53401006 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Aniline | HCID 6115 | 397.9% |
| Product | 3-Chloro-4-[(1,3-thiazol-2-yl)methoxy]aniline | HCID 53401110 | — |
Reaction Steps
3-Chloro-4-(thiazol-2-ylmethoxy)-phenylamine is prepared by added Zn dust (55.9 g, 856 mmol) to a mixture of 2-(2-chloro-4-nitro-phenoxymethyl)-thiazole (47.0 g, 190 mmol) in 5:1 MeOH:saturated aqueous NH4Cl solution (600 ml). After 2 h, the reaction mixture is filtered, and the filtrate concentrated. The resulting solid is triturated with water to give 3-chloro-4 thiazol-2-ylmethoxy)-phenylamine (35.2 g, 85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07501427B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-fdaaf12318204a90ac517e6ccd5a3a9a |
| Source note | uspto-grants-2009_03 |