Water → HCID 68819203, compound

Participants

Reaction Steps

The suspension of 5-quinazolin-6-ylmethylene-2-thioxo-thiazolidin-4-one (example 1b, 2.6 g, 9.52 mmol), iodomethane (1.2 mL, 19.0 mmol) and diisopropylethylamine (DIEA) (2.4 mL, 14.3 mmol) in anhydrous ethanol (100 mL) was stirred at room temperature for 12 h. After adding water (200 mL), the solid was collected by filtration, washed with water and dried to obtain 2-methylsulfanyl-5-quinazolin-6-ylmethylene-thiazol-4-one (2.5 g, 92%) as a black solid. LC-MS m/e 288 (MH+).

Provenance & Evidence