HCID 21106512, compound → HCID 21106487, compound

HRID 1783675Notes

Reaction equation

HRID 1783675 reaction equation
C(OC([N:8]([C:26]1[CH:30]=[C:29]([CH3:31])[N:28](C(OC(C)(C)C)=O)[N:27]=1)[C:9]1[C:18]2[C:13](=[CH:14][C:15]([C:19]([OH:21])=[O:20])=[CH:16][CH:17]=2)[C:12](=[O:22])[N:11]([CH:23]([CH3:25])[CH3:24])[N:10]=1)=O)(C)(C)C>C(O)(C(F)(F)F)=O.C(Cl)Cl>[CH:23]([N:11]1[C:12](=[O:22])[C:13]2[C:18](=[CH:17][CH:16]=[C:15]([C:19]([OH:21])=[O:20])[CH:14]=2)[C:9]([NH:8][C:26]2[CH:30]=[C:29]([CH3:31])[NH:28][N:27]=2)=[N:10]1)([CH3:25])[CH3:24]

Participants

3

Reactant 1

HCID 21106512HCID 21106512, compound

Product 1

HCID 21106487HCID 21106487, compound

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

1-[tert-Butoxycarbonyl-(1-tert-butoxycarbonyl-5-methyl-1H-pyrazol-3-yl)-amino]-3-isopropyl-4-oxo-3,4-dihydro-phthalazine-6-carboxylic acid (13.0 mg, 0.02 mmol) was dissolved in a 20% TFA/DCM solution (2 ml) and the reaction mixture was stirred for 48 hours. After this time, the reaction mixture was concentrated and the resulting residue was triturated with diethyl ether to give the title compound (Example M-1) as a white solid. 1H-NMR: (400 MHz, D6- DMSO), 9.34(1H, s), 8.73 (1H, s), 8.47 (1H, d), 8.26 (1H, d), 6.28 (1H, s), 5.20-5.17 (1H, m), 2.19 (3H, s), 1.26 (6H, d) MS (ESI+)=(M+H)+ 328.31.

Workup

  1. concentrationAfter this time, the reaction mixture was concentrated
  2. customthe resulting residue was triturated with diethyl ether

Sources & evidence

ORD record
ord-d2a1829b0ff74d888e124005d86356a3
Source dataset
uspto-grants-2009_03
Patent number
US07501410B2

Reaction notes

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