Phenylboronic Acid → HCID 178515029, compound

Participants

Reaction Steps

4-Hydroxy-2-(4-iodophenyl)-2H-phthalazin-1-one (0.1 g, 0.3 mmol), phenyl boronic acid (0.04 g, 3 mmol), palladium black (0.02 g, 0.2 mmol) and KF (0.1 g, 18 mmol) were dissolved in MeOH (2 ml) and heated at reflux for 7 h. Removal of supernatant palladium by filtration, extraction with H2O and subsequent filtration of the precipitated solid yielded the desired title compound (0.07 g, 78% yield) as a white solid. 1H-NMR: (400 MHz, D6-DMSO) 11.88 (1H, s), 8.33 (1H, d), 7.89-8.03 (3H, m), 7.78-7.86 (6H, m), 7.50 (2H, t), 7.39 (1H, t),; MS (ESI+)=315.3 (M+H)+.

Provenance & Evidence