HCID 21106535, compound → HCID 11611181, compound

HRID 1783684Notes

Reaction equation

HRID 1783684 reaction equation
C([N:5]1[C:9]([CH3:10])=[CH:8][C:7]([NH:11][C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[C:15](=[O:22])[N:14]([C:23]3[CH:28]=[CH:27][C:26]([C:29]4[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=4[CH3:35])=[CH:25][CH:24]=3)[N:13]=2)=[N:6]1)(C)(C)C>C(O)=O>[CH3:35][C:30]1[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=1[C:26]1[CH:25]=[CH:24][C:23]([N:14]2[N:13]=[C:12]([NH:11][C:7]3[CH:8]=[C:9]([CH3:10])[NH:5][N:6]=3)[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[C:15]2=[O:22])=[CH:28][CH:27]=1

Participants

3

Reactant 1

HCID 21106535HCID 21106535, compound

Product 1

HCID 11611181HCID 11611181, compoundYield 83%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

4-(1-tert-Butyl-5-methyl-1H-pyrazol-3-ylamino)-2-(2′-methyl-biphenyl-4-yl)-2H-phtalazin-1-one was deprotected with formic acid as described in Method O to give the title compound (0.036 g, 83% yield). 1H-NMR: (400 MHz, D6-DMSO) 9.29 (1H, s), 8.52 (1H, d), 8.40 (1H, d), 8.17 (1H, s), 7.97 (1H, t), 7.93 (1H, t), 7.82 (2H, d), 7.48 (2H, d), 7.30 (4H, m), 6.29 (1H, s), 2.33 (3H, s), 2.20 (3H, s); MS (ESI+)=408.16 (M+H)+.

Sources & evidence

ORD record
ord-c29b0c5d146943498ead1a1135d007a0
Source dataset
uspto-grants-2009_03
Patent number
US07501410B2

Reaction notes

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