Ethylene Glycol → HCID 21106520, compound

Participants

Reaction Conditions

Reaction Steps

4-Hydroxy-2-(4-iodo-phenyl)-2H-phthalazin-1-one (see Method Q) (0.20 g, 0.55 mmol), thiophenol (0.061 g, 0.55 mmol), CuI (0.006 g, 0.03 mmol) and ethylene glycol (0.070 g, 1.1 mmol) were dissolved in N-methyl-pyrrolidinone (NMP) (1 ml) under argon and heated to 90° C. Stirring at this temperature was continued for 26 h before the mixture was allowed to warm to RT. H2O (50 ml) was added and the resulting solution was extracted with DCM. The title compound was obtained after purification of the raw product by chromatography over silica gel with DCM (0.10 g, 54%). 1H-NMR: (400 MHz, D6-DMSO) 11.91 (1H, s), 8.30 (1H, s), 7.91-8.06 (3H, m), 7.69 (2H, d), 7.34-7.45 (7H, m); MS (ESI+)=347.26 (M+H)+.

Provenance & Evidence