HCID 178428369, compound → HCID 178428368, compound

Participants

Reaction Conditions

Reaction Steps

9 mg of N-[3-(4-tert-Butyl-phenyl)-1-(5-methyl-2H-pyrazol-3-ylamino)-4-oxo-3,4-dihydro-phthalazin-6-yl]-formamide (ZB-1) in a mixture of 0.5 ml MeOH and 0.5 ml conc. HCl were stirred at 50° C. for 2 hrs. The mixture was evaporated under vacuum and the residue dissolved in DCM. The DCM solution was washed with sodium bicarbonate solution and evaporated to yield 4 mg of the title product. 1H-NMR: (400 MHz, D6-DMSO) 11.8 (1H, br s), 8.81 (1H, s), 8.02 (1H, d), 7.52 (2H, d), 7.40 (2H, d), 7.34 (1H, d), 6.99 (1H, dd), 6.10 (br s, 2H), 2.10 (3H, s), 1.27 (9H, s); MS (ESI+)=389.21 (M+H)+.

Provenance & Evidence