HCID 57590905, compound → HCID 57590880, compound

Participants

Reaction Steps

tert-butyl[(2E)-3-(9-chloro-3-oxo-2,3-dihydro[1,2,4]triazolo[3,4-a]isoquinolin-6-yl)prop-2-en-1-yl]carbamate (3-10) was dissolved in CH3CN (10 mL) with 0.1% TFA present. The resulted solution was irradiated in microwave at 150° C. for 5 minutes. LCMS showed only product. The crude mixture was purified with reverse phase HPLC (H2O/CH3CN gradient w/0.1% TFA) to afford the desired product 3-11. 1H NMR (500 MHz, CD3OD) δ 8.29 (d, 1H, J=2.9 Hz), 7.90 (d, 1H, J=8.5 Hz), 7.78-7.64 (m, 2H), 7.14 (d, 1H, J=16.5 Hz), 6.30 (dt, 1H, J=16.5 , 7.0 Hz), 3.83 (d, 2H, J=7.0 Hz). LRMS m/z (M+H) 275.1 found, 275.1 required.

Provenance & Evidence