Cesium carbonate → HCID 57590934, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of tert-butyl 3,5-dioxo-5,6-dihydrobenzo[g][1,2,4]triazolo[4,3-c]quinazoline-2(3H)-carboxylate (8-6, 28 mg, 0.079 mmol, 1 equiv), cesium carbonate (100 mg, 0.31 mmol, 3.8 equiv), and N-(3-bromopropyl)carbamic acid tert-butyl ester (50 mg, 0.21 mmol, 2.6 equiv) in DMF (3 mL) was stirred at 23° C. for 16 h. The reaction mixture was filtered and the filtrate was concentrated and purified by reverse phase liquid chromatography (H2O/CH3CN gradient w/0.1% TFA present) to yield tert-butyl 6-{3-[(tert-butoxycarbonyl)amino]propyl}-3,5-dioxo-5,6-dihydrobenzo[g][1,2,4]triazolo[4,3-c]quinazoline-2(3H)-carboxylate (8-7).

Provenance & Evidence