反应详情

2-Chloro-5-nitrobenzenesulphonamide (5 g) prepared in the Step above is introduced into a hermetically closed vessel containing a mixture of dioxane (70 mL) and cyclopropylamine (3.5 mL). The hermetically closed vessel is placed in an oven at 100° C. for 24 hours. After this time period, the solvent and the reagent are removed by concentrating under reduced pressure. The residue is taken up in methanol (20 mL) and the insoluble material, which contains the title product, is collected by filtration, washed with methanol and dried.

1. additionabove is introduced into a hermetically closed vessel
2. additioncontaining
3. customAfter this time period, the solvent and the reagent are removed
4. concentrationby concentrating under reduced pressure
5. filtrationis collected by filtration
6. washwashed with methanol
7. customdried