HCID 57590734, compound → HCID 67519890, compound

Participants

Reaction Steps

A 100 ml round bottom flask was charged with the 1-[6-(3-methoxyphenyl)imidazo [2,1-b][1,3]thiazol-5-yl]ethanone (17.95 g, 62 mmol) and dimethylformamide dimethylacetal (120 ml). The mixture was refluxed for 72 hours and then cooled to room temperature. The mixture was concentrated in vacuo and the residue was purified by flash chromatography (ethyl acetate), giving a pale yellow solid (16.82 g). 300 MHz 1H NMR (DMSO-d6) δ: 8.40 (d, J=4.4 Hz, 1H), 7.59 (d, J=12.5 Hz, 1H), 7.41 (d, J=4.4 Hz, 1H), 7.37 (t, J=7.7 Hz, 1H), 7.17-7.21 (m, 2H), 6.99-7.03 (m, 1H), 5.15 (d, J=12.5 Hz, 1H), 3.79 (s, 3H), 3.04 (s, 3H), 2.44 (s, 3H).

Provenance & Evidence