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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1783951Generated: October 31, 2026

(5-Carbamoylthiophen-3-yl)boronic acid → 4-{8-[4-(4-(Cyclopropylmethyl)piperazin-1-yl)-phenylamino]-[1,2,4]triazolo[1,5-a]pyrazin-5-yl}thiophene-2-carboxylic acid amide

https://huagongshe.com/reaction/1783951

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(5-Carbamoylthiophen-3-yl)boronic acidHCID 67047388—
Reactant{4-[4-(Cyclopropylmethyl)piperazin-1-yl]phenyl}-[5-(1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-8-yl]amineHCID 135900377—
Product4-{8-[4-(4-(Cyclopropylmethyl)piperazin-1-yl)-phenylamino]-[1,2,4]triazolo[1,5-a]pyrazin-5-yl}thiophene-2-carboxylic acid amideHCID 24888611—

Reaction Steps

This compound may be prepared using methods as described for Compound 46, using 2-(aminocarbonyl)thiophene-4-boronic acid. LCMS: Rt=0.93 (95%), m/z (ESI) 475 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07501411B2
Source datasetuspto-grants-2009_03
ORD IDord-9b56b59d5fa145af9eed651afa727787
Source noteuspto-grants-2009_03