Diisopropylethylamine → (5-Bromo[1,2,4]triazolo[1,5-a]pyrazin-8-yl)-[4-(4-isopropylpiperazin-1-yl)-phenyl]amine

Participants

Role	Name	HCID	Charge
Reactant	Diisopropylethylamine	HCID 81531	—
Reactant	4-[4-(Propan-2-yl)piperazin-1-yl]aniline	HCID 9161545	—
Reactant	5,8-Dibromo-(1,2,4)triazolo(1,5-a)pyrazine	HCID 49758022	—
Reactant	4-{8-[4-(4-Methyl-piperazin-1-yl)-phenylamino]-[1,2,4]triazolo[1,5-a]pyrazin-5-yl}-thiophene-2-carboxylic acid amide	HCID 57589928	—
Solvent	Diethyl Ether	HCID 3283	—
Solvent	Isopropanol	HCID 3776	—
Product	(5-Bromo[1,2,4]triazolo[1,5-a]pyrazin-8-yl)-[4-(4-isopropylpiperazin-1-yl)-phenyl]amine	HCID 57590046	—

Reaction Conditions

Temperature	95 °C

Reaction Steps

This compound may be prepared using methods as described for Compound 6, step 1, using 5,8-dibromo-[1,2,4]triazolo[1,5-a]pyrazine (2 g, 7.20 mmol), 4-(4-isopropyl-piperazin-1-yl)-phenylamine (1.89 g, 8.62 mmol) and N,N-diisopropylethylamine (1.88 mL, 10.8 mmol) in 2-propanol (30 mL) are stirred at 95° C. overnight. The title compound is isolated after trituration with diethyl ether and petroleum ether as a grey solid (2.59 g, 87%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07501411B2
Source dataset	uspto-grants-2009_03
ORD ID	ord-2451d9c658d64830b9e953833027103d
Source note	uspto-grants-2009_03