(4-{8-[4-(4-Isopropylpiperazin-1-yl)-phenylamino]-[1,2,4]triazolo[1,5-a]pyrazin-5-yl}pyridin-2-yl)methanol → (4-{8-[6-(4-Isopropylpiperazin-1-yl)pyridin-3-ylamino]-[1,2,4]triazolo[1,5-a]pyrazin-5-yl}pyridin-2-yl)methanol

HRID 1783983Notes

Reaction equation

HRID 1783983 reaction equation
[CH:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2C=[CH:14][C:13]([NH:16][C:17]3[C:18]4[N:19]([N:31]=[CH:32][N:33]=4)[C:20]([C:23]4[CH:28]=[CH:27][N:26]=[C:25]([CH2:29][OH:30])[CH:24]=4)=[CH:21][N:22]=3)=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)([CH3:3])[CH3:2].BrC1N2N=CN=C2C(NC2C=NC(N3CCN(C(C)C)CC3)=CC=2)=[N:37]C=1>>[CH:1]([N:4]1[CH2:5][CH2:6][N:7]([C:10]2[N:37]=[CH:14][C:13]([NH:16][C:17]3[C:18]4[N:19]([N:31]=[CH:32][N:33]=4)[C:20]([C:23]4[CH:28]=[CH:27][N:26]=[C:25]([CH2:29][OH:30])[CH:24]=4)=[CH:21][N:22]=3)=[CH:12][CH:11]=2)[CH2:8][CH2:9]1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 24890468(4-{8-[4-(4-Isopropylpiperazin-1-yl)-phenylamino]-[1,2,4]triazolo[1,5-a]pyrazin-5-yl}pyridin-2-yl)methanolHCID 57590080(5-Bromo-[1,2,4]triazolo[1,5-a]pyrazin-8-yl)-[6-(4-isopropylpiperazin-1-yl)pyridin-3-yl]amine

Product 1

HCID 24890292(4-{8-[6-(4-Isopropylpiperazin-1-yl)pyridin-3-ylamino]-[1,2,4]triazolo[1,5-a]pyrazin-5-yl}pyridin-2-yl)methanol

Procedure

This compound may be prepared using the methods as described for Compound 83, using (5-bromo-[1,2,4]triazolo[1,5-a]pyrazin-8-yl)-[6-(4-isopropylpiperazin-1-yl)pyridin-3-yl]amine in Step 4. LCMS: Rt=0.71 min (95%), m/z (ESI) 446 (M+H)+.

Workup

  1. customThis compound may be prepared

Sources & evidence

ORD record
ord-9d1c0d6110ae46b5bac3913ab9dccf45
Source dataset
uspto-grants-2009_03
Patent number
US07501411B2

Reaction notes

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