HRID1784003

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID57589996

未命名化合物

结构：CC(C)N1CCN(c2ccc(Nc3ncc(Br)n4ncnc34)cc2)CC1

HCID57590046

未命名化合物

HCID178514824

未命名化合物

PRODUCTS

生成物

结构：CC(C)N1CCN(c2ccc(Nc3ncc(-c4ccc5c(c4)C(C)(C)NC5=O)n4ncnc34)cc2)CC1

HCID24889626

未命名化合物

PROCEDURE

实验过程

5-Bromo-3,3-dimethyl-2,3-dihydroisoindol-1-one is converted to the corresponding boronate in a fashion analogous to Intermediate 6, Step 3. This is then used to prepare the title compound from (5-bromo[1,2,4]triazolo[1,5-a]pyrazin-8-yl)-[4-(4-isopropylpiperazin-1-yl)-phenyl]amine using methods as described for Compound 120, Step 4. LCMS: Rt=0.92 (100%), m/z=497 (M+H)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-405bef0570904f9abc44789b427e7f09
来源数据集: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07501411B2
来源说明: uspto-grants-2009_03

反应 SMILES

Br[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[NH:6][C:5]2([CH3:13])[CH3:12].B([O-])[O-].Br[C:18]1[N:23]2[N:24]=[CH:25][N:26]=[C:22]2[C:21]([NH:27][C:28]2[CH:33]=[CH:32][C:31]([N:34]3[CH2:39][CH2:38][N:37]([CH:40]([CH3:42])[CH3:41])[CH2:36][CH2:35]3)=[CH:30][CH:29]=2)=[N:20][CH:19]=1>>[CH:40]([N:37]1[CH2:36][CH2:35][N:34]([C:31]2[CH:30]=[CH:29][C:28]([NH:27][C:21]3[C:22]4[N:23]([N:24]=[CH:25][N:26]=4)[C:18]([C:2]4[CH:3]=[C:4]5[C:8](=[CH:9][CH:10]=4)[C:7](=[O:11])[NH:6][C:5]5([CH3:13])[CH3:12])=[CH:19][N:20]=3)=[CH:33][CH:32]=2)[CH2:39][CH2:38]1)([CH3:42])[CH3:41]