Benzylamine → N-Benzyl-2-methoxy-4-[5-(1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamino]-benzamide

HRID 1784014Notes

Reaction equation

HRID 1784014 reaction equation
[CH3:1][O:2][C:3]1[CH:19]=[C:18]([NH:20][C:21]2[C:22]3[N:23]([N:32]=[CH:33][N:34]=3)[C:24]([C:27]3[CH:28]=[N:29][NH:30][CH:31]=3)=[CH:25][N:26]=2)[CH:17]=[CH:16][C:4]=1[C:5]([NH:7][CH2:8][C:9]1[CH:10]=N[C:12]([CH3:15])=[CH:13][CH:14]=1)=[O:6].C(N)C1C=CC=CC=1>>[CH2:8]([NH:7][C:5](=[O:6])[C:4]1[CH:16]=[CH:17][C:18]([NH:20][C:21]2[C:22]3[N:23]([N:32]=[CH:33][N:34]=3)[C:24]([C:27]3[CH:31]=[N:30][NH:29][CH:28]=3)=[CH:25][N:26]=2)=[CH:19][C:3]=1[O:2][CH3:1])[C:9]1[CH:10]=[CH:15][CH:12]=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 7504BenzylamineHCID 1359796172-Methoxy-N-(6-methylpyridin-3-yl)methyl-4-[5-(1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamino]-benzamide

Product 1

HCID 135979592N-Benzyl-2-methoxy-4-[5-(1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamino]-benzamide

Procedure

This compound may be prepared using the methods described for Compound 120, using benzylamine in step 1. LCMS: Rt 1.62 min (100%) m/z (ESI) 440 (M+H)+.

Workup

  1. customThis compound may be prepared

Sources & evidence

ORD record
ord-873f23cfc9084ae2bf7e9ba4c604e5c3
Source dataset
uspto-grants-2009_03
Patent number
US07501411B2

Reaction notes

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