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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1784020Generated: October 30, 2026

(5-Carbamoylthiophen-3-yl)boronic acid → 4-[8-(6-Phenylacetylamino-pyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyrazin-5-yl]-thiophene-2-carboxylic acid amide

https://huagongshe.com/reaction/1784020

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(5-Carbamoylthiophen-3-yl)boronic acidHCID 67047388—
ReactantN-[5-(5-bromo-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamino)-pyridin-2-yl]-2-phenylacetamideHCID 86619666—
Reactant2-Methoxy-N-(6-methylpyridin-3-yl)methyl-4-[5-(1H-pyrazol-4-yl)-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamino]-benzamideHCID 135979617—
Product4-[8-(6-Phenylacetylamino-pyridin-3-ylamino)-[1,2,4]triazolo[1,5-a]pyrazin-5-yl]-thiophene-2-carboxylic acid amideHCID 57590020—

Reaction Steps

This compound may be prepared using methods as described for Compound 120, step 4, using N-[5-(5-bromo-[1,2,4]triazolo[1,5-a]pyrazin-8-ylamino)-pyridin-2-yl]-2-phenylacetamide and 2-(aminocarbonyl)thiophene-4-boronic acid. LCMS: Rt 1.06 min (100%) m/z (ESI) 471 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07501411B2
Source datasetuspto-grants-2009_03
ORD IDord-de4280073ef14b95aee133186ee3a2e6
Source noteuspto-grants-2009_03