Hydrochloric Acid → HCID 66882141, compound

Participants

Reaction Steps

A solution of 80 mg (0.16 mmol) of (1RS,2RS,3SR)-2-(4-chloro-phenylcarbamoyl)-3-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-cyclopropanecarboxylic acid ethyl ester (example 68) in a mixture of 10 ml of THF and 10 ml of a 1M aqueous LiOH-solution was stirred during 2 hrs at room temperature. The mixture was poured into 50 ml of a aqueous HCl-solution (0.5 M), extracted with AcOEt and the combined organic phases were dried over Na2SO4. Evaporation of the solvent gave 65 mg (86%) of the title compound. Off-white solid. MS: 468 (M−H)−.

Provenance & Evidence