Hydrochloric Acid → HCID 66881522, compound

Participants

Reaction Steps

A solution of 68 mg (0.14 mmol) of (1RS,2SR,3RS)-2-(5-chloro-pyridin-2-ylcarbamoyl)-3-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-cyclopropanecarboxylic acid methyl ester (example 114, step 5) in 1.5 ml of THF was treated with 0.2 ml of a 1M aqueous LiOH solution, stirred at RT during 2 hrs and acidified to pH ca. 2 with aqueous HCl. Extraction with AcOEt, drying of the combined organic phases over Na2SO4, filtration and evaporation of the solvent gave 45 mg (68%) of (1RS,2SR,3SR)-2-(5-chloro-pyridin-2-ylcarbamoyl)-3-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-cyclopropanecarboxylic acid. Light yellow crystalline. MS: 469 (M−H)−.

Provenance & Evidence