HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-amino-3-fluoro-phenyl)-4-benzyloxy-1H-pyridin-2-one → 1-(4-Amino-3-fluoro-phenyl)-4-hydroxy-1H-pyridin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-amino-3-fluoro-phenyl)-4-benzyloxy-1H-pyridin-2-one | HCID 66882413 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-(4-Amino-3-fluoro-phenyl)-4-hydroxy-1H-pyridin-2-one | HCID 66881543 | 97% |
Reaction Steps
A solution of 580 mg (1.87 mmol) 1-(4-amino-3-fluoro-phenyl)-4-benzyloxy-1H-pyridin-2-one (example 144, step 1) in 20 ml of MeOH was treated with 140 mg of Pd/C (10%) and hydrogenated at atmospheric pressure under vigorous stirring for 3 hrs. Filtration and evaporation of the solvent gave 398 mg (97%) of 1-(4-Amino-3-fluoro-phenyl)-4-hydroxy-1H-pyridin-2-one. Light brown solid. MS: 221 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07501413B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-581c221020e9422f95f707d475439026 |
| Source note | uspto-grants-2009_03 |