Methyl iodide → HCID 68851119, compound

Participants

Reaction Steps

A solution of 90 mg (0.19 mmol) of (1S,2R,3R) 2-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-3-(4-methoxy-phenoxymethyl)-cyclopropanecarboxylic acid in 3 ml of DMF was treated with 100 mg of K2CO3 and 0.5 ml ml of iodomethane. The mixture was stirred for 3 hrs and poured into a diluted aqueous solution of NaOH. Extraction with AcOEt, drying of the combined organic phases over Na2SO4, filtration and evaprotation of the solvent gave 90 mg (97%) of (1S,2R,3R) 2-[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenylcarbamoyl]-3-(4-methoxy-phenoxymethyl)-cyclopropanecarboxylicacid methyl ester. Yellow oil. MS: 467 (M+H)+.

Provenance & Evidence