2-Methoxyaniline → 9-Methoxy-2-(2-methoxy-phenylamino)-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one

Participants

Role	Name	HCID	Charge
Reactant	2-Methoxyaniline	HCID 7000	—
Reactant	2-chloro-9-methoxy-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-4-one	HCID 57591093	—
Product	9-Methoxy-2-(2-methoxy-phenylamino)-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one	HCID 11325536	—

Reaction Steps

The title compound was prepared from 2-chloro-9-methoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one (4) and 2-methoxy-aniline as in Example 1 d. 1H-NMR (400 MHz, d6-DMSO) 88.74 (s, 1H), 8.24 (br, 1H), 7.69 (d, 1H), 7.12-6.92 (5H), 6.70 (br, 1H), 3.97 (t, 2H), 3.87 (s, 3H), 3.84 (s, 3H) and 2.96 (t, 2H); MS (ESI) (M+H)+ 350.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07501512B2
Source dataset	uspto-grants-2009_03
ORD ID	ord-e9e6ae9ae5d84a0db20bb294f7ccb050
Source note	uspto-grants-2009_03