5-Aminoquinoline → 9-Methoxy-2-(quinolin-5-ylamino)-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one

Participants

Role	Name	HCID	Charge
Reactant	5-Aminoquinoline	HCID 11911	—
Reactant	2-chloro-9-methoxy-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-4-one	HCID 57591093	—
Product	9-Methoxy-2-(quinolin-5-ylamino)-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one	HCID 11372138	—

Reaction Steps

The title compound was prepared from 2-chloro-9-methoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one (4) and 5-amino-quinoline as in Example 1 d. 1H-NMR (400 MHz, d6-DMSO) δ 9.68 (br, 1H), 8.93 (dd, 1H), 8.47 (d, 1H), 7.89 (2H), 7.79 (t, 1H), 7.70 (d, 1H), 7.57 (dd, 1H), 7.03-6.97 (2H), 6.49 (br, 1H), 3.97 (t, 2H), 3.84 (s, 3H) and 2.97 (t, 2H); MS (ESI) (M+H)+ 371.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07501512B2
Source dataset	uspto-grants-2009_03
ORD ID	ord-ffc01c1b489b4d53a6148a0d3a600342
Source note	uspto-grants-2009_03