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(2-Bromophenyl)hydrazine → 2-[N'-(2-Bromo-phenyl)-hydrazino]-9-methoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (2-Bromophenyl)hydrazine | HCID 85583 | — |
| 反応物 | 2-chloro-9-methoxy-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-4-one | HCID 57591093 | — |
| 生成物 | 2-[N'-(2-Bromo-phenyl)-hydrazino]-9-methoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one | HCID 57591099 | — |
反応手順
The title compound was prepared from 2-chloro-9-methoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one (4) and (2-bromo-phenyl)-hydrazine as in Example 1 d. 1H-NMR (400 MHz, d6-DMSO at 60° C.) δ 9.19 (br, 1H), 7.66 (brd, 1H), 7.46 (d, 1H), 7.44 (br, 1H), 7.20 (t, 1H), 6.98-6.75 (3H), 6.71 (t, 1H), 6.23 (s, 1H), 3.94 (t, 2H), 3.82 (s, 3H) and 2.93 (t, 2H); MS (ESI) (M+H)+ 413, 415.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07501512B2 |
| 出典データセット | uspto-grants-2009_03 |
| ORD ID | ord-c16444c92ddc4fdfa9dee910b7189801 |
| 出典メモ | uspto-grants-2009_03 |