Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 9-Methoxy-2-(2-pyrrolidin-1-yl-ethylamino)-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | 1-Pyrrolidineethanamine | HCID 1344 | — |
| 반응물 | 2-chloro-9-methoxy-6,7-dihydro-4H-pyrimido[6,1-a]isoquinolin-4-one | HCID 57591093 | — |
| 생성물 | 9-Methoxy-2-(2-pyrrolidin-1-yl-ethylamino)-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one | HCID 11256309 | — |
반응 단계
The title compound was prepared from 2-chloro-9-methoxy-6,7-dihydro-pyrimido[6, 1-a]isoquinolin-4-one (4) and 2-pyrrolidin-1-yl-ethylamine as in Example 1 d, followed by treatment with HCl. 1H-NMR (400 MHz, dB-DMSO) δ 7.64 (d, 1H), 7.59 (br, 1H), 7.00-6.92 (2H), 6.18 (s, 1H), 3.92 (t, 2H), 3.82 (s, 3H), 3.46 (m, 2H), 2.91 (t, 2H), 2.90-2.50 (6H) and 1.76 (4H); MS (ESI) (M+H)+ 341.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07501512B2 |
| 출처 데이터셋 | uspto-grants-2009_03 |
| ORD ID | ord-1e5338f5ebdd4ad69327ba6377e40e8b |
| 출처 메모 | uspto-grants-2009_03 |