Methanol → HCID 57591094, compound

Participants

Reaction Steps

To a solution of 2-(3-nitro-phenylamino)-9-methoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one (5) (525.4 mg, 1.4 mmol) in AcOH (40 mL), Zn powder (ca. 300 mg) was added and stirred at room temperature for 3 hrs, then at 40° C. overnight. After cooling, MeOH was added to the mixture and insoluble materials were removed by filtration. The MeOH solution was purified on BondElut® SCX (Varian Incorporated) then passed through BondElut® NH2 (Variant Incorporated). Result solid was washed with MeOH to give the title compound (215.1 mg, 46%). MS (ESI) (M+H)+ 335.

Provenance & Evidence