2,4,6-Trichlorobenzoyl chloride → HCID 11465112, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 2-amino-9-methoxy-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one (7) (40 mg, 0.16 mmol) in CHCl3 (3 mL), DMAP (30.1 mg, 0.24 mmol) and 2,4,6-trichlorobenzoyl chloride (37.5 uL, 0.24 mmol) was added and stirred at 25° C. overnight. After cooling, the mixture was purified on BondElut® SCX (Varian Incorporated) then column chromatography on silica gel (CHCl3/MeOH=50/1 as eluant) to give the title compound (17.1 mg, 24%). 1H-NMR (400 MHz, CDCl3) δ 7.90 (d, 1H), 7.42 (s, 2H), 6.95 (dd, 1H), 6.82 (d, 1H), 4.27 (t, 2H), 3.90 (s, 3.17) and 3.03 (t, 2H); MS (ESI) (M+H)+ 449.

Provenance & Evidence