Acetyl chloride → HCID 67530107, compound

HRID 17841Notes

Reaction equation

HRID 17841 reaction equation
[C:1](Cl)(=[O:3])[CH3:2].[NH2:5][C:6]1[CH:20]=[CH:19][C:9]2[N:10]([CH:16]3[CH2:18][CH2:17]3)[CH:11]=[N:12][S:13](=[O:15])(=[O:14])[C:8]=2[CH:7]=1>O1CCOCC1>[C:1]([NH:5][C:6]1[CH:20]=[CH:19][C:9]2[N:10]([CH:16]3[CH2:17][CH2:18]3)[CH2:11][NH:12][S:13](=[O:15])(=[O:14])[C:8]=2[CH:7]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 675289727-amino-4-cyclopropyl-4H-1,2,4-benzothiadiazine 1,1-dioxide

Product 1

HCID 67530107HCID 67530107, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Acetyl chloride (0.5 mL) is added to a solution of 7-amino-4-cyclopropyl-4H-1,2,4-benzothiadiazine 1,1-dioxide (0.5 g), prepared in the Step above, in dioxane (20 mL) and stirring is carried out at ambient temperature for 16 hours. After removing the solvent by distillation under reduced pressure, the residue is taken up in water, and the precipitate, of 7-acetamido-4-cyclopropyl-4H-1,2,4-benzothiadiazine 1,1-dioxide, is collected by filtration, washed with water and dried. It is used directly in a subsequent step, according to the procedure described in Step D of Example 1, in order to obtain the expected product.

Workup

  1. customAfter removing the solvent
  2. distillationby distillation under reduced pressure
  3. filtrationthe precipitate, of 7-acetamido-4-cyclopropyl-4H-1,2,4-benzothiadiazine 1,1-dioxide, is collected by filtration
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-589de87b7a3f4586adf488e89c164d58
Source dataset
uspto-grants-2010_06
Patent number
US07741320B2

Reaction notes

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