Toluene → HCID 69051761, compound

HRID 1784115Notes

Reaction equation

HRID 1784115 reaction equation
S(O)(O)(=O)=O.[CH3:6][S:7][C:8]1[N:13]=[C:12]([NH2:14])[C:11]([NH2:15])=[C:10]([NH2:16])[N:9]=1.O.O.[Cl-:19].[Ba+2].[Cl-].C1(C)C=CC=CC=1>O>[ClH:19].[ClH:19].[NH2:16][C:10]1[C:11]([NH2:15])=[C:12]([NH2:14])[N:13]=[C:8]([S:7][CH3:6])[N:9]=1

Participants

5

Reactant 3

HCID 1140TolueneHCID 229265Sulfuric acid--2-(methylsulfanyl)pyrimidine-4,5,6-triamine (1/1)HCID 528434610326-27-9

Product 1

HCID 69051761HCID 69051761, compoundYield 209.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
80 °C

Procedure

To a suspension of a 2-methylmercapto-4,5,6-triamino-pyrimidine sulfate (44.3 mmole), which may be prepared and characterised for instance as disclosed by Taylor et al. in J. Am. Chem. Soc. (1952) 74:1644-1647, in water (135 ml) at 80° C. was added dropwise a solution of barium chloride dihydrate (39.8 mmole) in water (25 ml). The suspension was stirred for 30 minutes at 80° C. The reaction mixture was cooled down and barium sulfate was filtered off over Celite. The filtrate was evaporated in vacuo and co-evaporated with toluene yielding the title compound as a yellow powder (10.2 g, 94% yield).

Workup

  1. custommay be prepared
  2. temperatureThe reaction mixture was cooled down
  3. filtrationbarium sulfate was filtered off over Celite

Sources & evidence

ORD record
ord-9cac5a6be1a440569a97960ad86d737e
Source dataset
uspto-grants-2009_03
Patent number
US07501513B2

Reaction notes

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