Hydrochloric Acid → 2-(3-Hydroxypropoxy)propan-1-ol

HRID 1784136ノート

反応式

HRID 1784136 の反応式
[OH:1][CH2:2][CH2:3][CH2:4][O:5][CH:6]([CH2:8][O:9]C(C)(C)C)[CH3:7].Cl>>[OH:1][CH2:2][CH2:3][CH2:4][O:5][CH:6]([CH2:8][OH:9])[CH3:7]

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 1643333-[(1-Tert-butoxypropan-2-yl)oxy]propan-1-ol

生成物 1

HCID 217585032-(3-Hydroxypropoxy)propan-1-ol収率 91.3%

実験手順

HO(CH2)3OCH(CH3)CH2OC(CH3)3 (203.39 g) prepared in Example 2-2 was loaded into a round-bottomed flask and stirred with 5 N hydrochloric acid (1 L) at room temperature for 43 hours. The reaction solution was concentrated with an evaporator, and then, after addition of toluene, concentrated again with an evaporator to give the title compound (131 g). The NMR spectrum data of the product were as follows.

後処理

  1. concentrationThe reaction solution was concentrated with an evaporator
  2. additionafter addition of toluene
  3. concentrationconcentrated again with an evaporator

出典と根拠

ORDレコード
ord-86d261b188c3472ea1e89fc68be3f816
出典データセット
uspto-grants-2009_03
特許番号
US07501540B2

反応ノート

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