HCID 57591440, compound → N-(3,4-Dimethoxy-phenyl)-2-phenyl-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-malonamic acid

HRID 1784145Notes

Reaction equation

HRID 1784145 reaction equation
C([O:8][C:9](=[O:42])[CH:10]([C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[C:11]([N:13]([C:26]1[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[C:28]([O:34][CH3:35])[CH:27]=1)[CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]([F:25])([F:24])[F:23])=[CH:18][CH:17]=1)=[O:12])C1C=CC=CC=1>C(OCC)(=O)C.C(O)(=O)C.[Pd]>[CH3:35][O:34][C:28]1[CH:27]=[C:26]([N:13]([CH2:14][CH2:15][C:16]2[CH:17]=[CH:18][C:19]([C:22]([F:23])([F:25])[F:24])=[CH:20][CH:21]=2)[C:11](=[O:12])[CH:10]([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[C:9]([OH:42])=[O:8])[CH:31]=[CH:30][C:29]=1[O:32][CH3:33]

Participants

5

Reactant 1

HCID 57591440HCID 57591440, compound

Product 1

HCID 57591457N-(3,4-Dimethoxy-phenyl)-2-phenyl-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-malonamic acid

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolventHCID 8857Ethyl AcetateSolvent

Procedure

0.35 g (0.62 mmol) N-(3,4-Dimethoxy-phenyl)-2-phenyl-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-malonamic acid benzyl ester in 20 mL ethyl acetate and 0.37 mL acetic acid was hydrogenated over Pd/C with atmospheric pressure of H2 for 16 h at room temperature. The catalyst was filtered off and the and the filtrate evaporated to dryness. The acid was used without further purification in the consecutive step. MS(m/e): 488.2 (MH+).

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe and the filtrate evaporated to dryness
  3. customThe acid was used without further purification in the consecutive step

Sources & evidence

ORD record
ord-42b4a92494f34c55aa383bde8206dcfe
Source dataset
uspto-grants-2009_03
Patent number
US07501541B2

Reaction notes

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