Triethylamine → N-(3,4-Dimethoxy-phenyl)-2-methyl-2-phenyl-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-malonamic acid ethyl ester

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Reaction Steps

A mixture of 97.5 mg (0.3 mmol) (3,4-dimethoxy-phenyl)-[2-(4-trifluoromethyl-phenyl)-ethyl]-amine (intermediate 1), 101 mg (0.45 mmol) 2-chlorocarbonyl-2-phenyl-propionic acid ethyl ester (Journal of Organic Chemistry (1959), 24 109-10) and 121 mg (1.2 mmol) triethylamine 15 mL DCM was stirred for 16 h at room temperature. The mixture was evaporated and purified by preparative HPLC on reversed phase eluting with a gradient formed from acetonitrile, water and formic acid, the product containing fractions were evaporated to yield 71.5 mg (45%) of the title compound. MS(m/e): 530.2 (MH+).

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