HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Benzoate → HCID 68862922, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Benzoate | HCID 7150 | — |
| Reactant | Methyl 5-bromosalicylate | HCID 77683 | — |
| Reactant | 3-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride) | HCID 2734660 | — |
| Reactant | HCID 86596784 | HCID 86596784 | — |
| Product | HCID 68862922 | HCID 68862922 | — |
Reaction Steps
The resin-bound 3′-chloro-4′-fluoro-4-hydroxy-biphenyl-3-carboxylic acid methyl ester was prepared with 1.0 g (3.0 mmol) of above resin-bound 5-bromo-2-hydroxy-benzoic acid methyl ester and 1.6 g (9.0 mmol) of 3-chloro-4-fluoro-phenylboronic acid as described in Procedure K. The resulting resin-bound methyl benzoate was hydrolyzed with LiOH/H2O/THF/ethanol at rt for 3 days.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07501538B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-03f5875dd8004e5d8769e7b6f33d3805 |
| Source note | uspto-grants-2009_03 |