Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | HCID 68859688 | HCID 68859688 | — |
| Solvent | MeOH tetrahydrofuran | HCID 21899815 | — |
| Product | HCID 11650315 | HCID 11650315 | 59.4% |
Reaction Steps
(S)-2-[2-(biphenyl-4-ylmethoxy)-benzoylamino]-3-[4-(biphenyl-4-ylmethoxy)-phenyl]-propionic acid methyl ester (50 mg, 0.077 mmol) was dissolved in 5 mL of THF-MeOH (4-1), cooled to 0° C. and 1.1 equiv of 2 N LiOH added. After 30 minutes, 3.2 additional equiv of 2N LiOH was added and the reaction stirred for 30 minutes. The reaction was worked up according to Procedure C to give 29 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07501538B2 |
|---|
| Source dataset | uspto-grants-2009_03 |
|---|
| ORD ID | ord-d365ed09cedf475a99efb78cc739170f |
|---|
| Source note | uspto-grants-2009_03 |
|---|
