2-Methylpentaldehyde → HCID 11570490, compound

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Reaction Steps

(2S)-[5-chloro-2-(2-methyl-pentylamino)-benzoylamino]-3-(2′-phenoxy-biphenyl-4-yl)-propionic acid methyl ester was prepared following procedure G using (2S)-(2-amino-5-chloro-benzoylamino)-3-(2′-phenoxy-biphenyl-4-yl)-propionicacid methyl ester (100 mg, 0.2 mmol) prepared in Example 10, 2-methyl-pentanal (30 mg, 0.25 mmol) in DCE (4 mL). Purification by flash chromatography (ethyl acetate/hexanes 1:3) gave the title compound as a thick liquid, which was hydrolyzed according to Procedure C yielding the title compound (85 mg). LC/MS (m/z): 571 (M+1)+.

Provenance & Evidence