HCID 57592135, compound → HCID 57592119, compound

Participants

Reaction Steps

To a solution of 6-fluoro-5-hydroxy-4-nitro-hexanoic acid amide (0.5 g, 2.58 mmol) in MeOH (20 mL) was added Raney Ni (about 200 mg), and the mixture was shaken under H2 (40-45 psi) at room temperature for 6 h. It was filtered and the catalyst was washed with MeOH (3×10 mL). The MeOH solution was evaporated and the residue oil (435 mg) was used without further purification. 1H NMR (acetone-d6): 6.85 (bs, NH, 1H), 6.15 (bs, NH, 1H), 4.70-4.25 (m, 3H), 3.65-3.50 (m, 1H), 2.86 (bs, 2H), 2.40-2.20 (m, 4H).

Provenance & Evidence