6-Fluoro-5-hydroxy-4-nitro-hexanoic acid dimethylamide → 4-Amino-6-Fluoro-5-Hydroxy-Hexanoic Acid Dimethylamide

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Reaction Steps

To a solution of 6-fluoro-5-hydroxy-4-nitro-hexanoic acid dimethylamide (1.22 g, 5.5 mmol) in MeOH (20 mL) was added Ranny Ni (about 500 mg), and the mixture was hydrogenated under 40-45 psi H2 at room temperature for 6 h. The catalyst was removed. The MeOH solution was evaporated and the residue oil (0.92 g, yield 87%) was used without further purification. MS m/e 193 (M+1).

Provenance & Evidence