2-Methoxyethanol → HCID 178486869, compound

Participants

Reaction Steps

2-amino-4,5-dimethylbenzoic acid (37)(5 g, 25.30 mmol) and formamidine acetate (5.2 g, 50.00 mmol) were dissolved in 2-methoxyethanol (80 ml) and the mixture heated to reflux for 16 hours. The mixture was cooled and concentrated in vacuo and suspended in a small volume of water. Sodium bicarbonate (5% aqueous solution) was added carefully (gas evolution) until pH 7 was attained. The suspension was filtered and the filtercake washed with water to give the title compound (4.50 g, 86.2%) as a brown powder which required no further purification. m/z (LC-MS, ESP): 207 [M+H]+, R/T=3.16 mins

Provenance & Evidence