Morpholine → HCID 57592528, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-(5-Bromo-furan-2-yl)-2,6-dichloro-pyrimidine (1.93 g, 6.51 mmol) in DMA (35 ml) was added morpholine (2.83 g, 32.54 mmol) and N,N-diisopropylethylamine (4.21 g, 32.54 mmol). The reaction mixture was heated to 70° C. for 7 hours whereupon it was cooled and diluted with EtOAc (100 ml) and then washed with water (2×50 ml), dried (MgSO4), filtered and concentrated in vacuo to give a dark oil. The crude residue was purified by flash chromatography (SiO2) (1:3—EtOAc:Hexanes) to give the title compound as a white crystalline solid (0.95 g, 37%). m/z (LC-MSW, ESP):396 [M+H]+, R/T=4.38 mins.

Provenance & Evidence