Hydrogen Bromide → HCID 68831940, compound

Participants

Reaction Steps

A solution of D5 (300 mg, 0.86 mmol) in aqueous 48% HBr (10 mL) was heated at 120° C. overnight. The mixture was cooled to room temperature and the solvent removed, azeotroping with toluene. Diethyl ether was added to the residue to yield the title compound D6 as the hydrobromide salt (340 mg). MH+ 336. 1H NMR δ (DMSO-d6) 2.75 (3H, d), 2.88-3.25 (6H, m), 3.50-3.66 (2H, m), 7.35-7.50 (2H, t), 7.76 (1H, s), 7.90-8.03 (2H, m), 9.85 (1H, br.s), 10.80 (1H, br.s).

Provenance & Evidence