Hydrochloric Acid → 4-Methoxyphthalic acid

Participants

Reaction Steps

A solution of dimethyl 4-methoxyphthalate (20 g, 89 mmol) was heated at reflux in 10% aqueous sodium hydroxide (85 mL) for 1 hour. The mixture was cooled to room temperature then acidified to pH 1 using concentrated hydrochloric acid. The precipitate that formed was filtered off, washed with water and dried under vacuum to afford the title compound D22 (13.61 g). MH−195. 1H NMR δ (DMSO-de) 3.83 (3H, s), 7.05-7.10 (3H, m), 7.72 (1H, d).

Provenance & Evidence