Hydrazine → HCID 57593197, compound

Participants

Reaction Steps

The product from Step 9 (19), 95 mg (0.22 mmol) was dissolved in 3 ml of dry ethanol then 50 μl (1.6 mmol) of hydrazine was added and the reaction was left to stir at room temperature for 1 h then heated to 40° C. for 2.5 h. The precipitate was removed by filtration and washed with ethyl acetate and the solvent evaporated off resulting in 75 mg of crude 2-(1-amino-2-methylpropyl)-3-benzyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (20). This was purified on a silica column yielding 42 mg (0.13 mmol 63%) as a clear oil.

Provenance & Evidence