Benzenebutanamine → HCID 87567052, compound

HRID 1784516Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[C:11]([P:14]([O:19][CH2:20][CH3:21])([O:16][CH2:17][CH3:18])=[O:15])([F:13])[F:12])[C:5](O)=[O:6].[CH2:22]([NH2:32])[CH2:23][CH2:24][CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[CH2:20]([O:19][P:14]([C:11]([C:10]1[CH:9]=[CH:8][C:4]([C:5](=[O:6])[NH:32][CH2:22][CH2:23][CH2:24][CH2:25][C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[CH:3][C:2]=1[Br:1])([F:13])[F:12])(=[O:15])[O:16][CH2:17][CH3:18])[CH3:21]

Participants

Reactant 2

HCID 83242Benzenebutanamine

HCID 57592230HCID 57592230, compound2×

Product 1

HCID 87567052HCID 87567052, compound

Procedure

The 3-bromo-4-[(diethoxyphosphoryl)difluoromethyl)benzoic acid (Compound 35) was coupled to phenbutyl amine following the procedures of Example 39 to give {[2-bromo-4-(4-phenylbutylcarbamoyl)phenyl]difluoromethyl}-phosphonic acid diethyl ester which was treated in a manner similar to Example 40 to give Compound 62. MS (ion spray):m/z 459.98/461.95 (M−H)

Sources & evidence

ORD record: ord-4524a489f9b44534838f0c7596a9c754
Source dataset: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07504389B2

Reaction notes

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