Water → (4-Methoxyphenyl)glyoxal

HRID 1784655Notes

Reaction equation

HRID 1784655 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]([C:7](=[O:10])[CH2:8]Br)=[CH:5][CH:4]=1.[OH2:13]>>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([CH:8]=[O:13])=[O:10])=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 962Water2×HCID 4965Bromomethyl 4-methoxyphenyl ketone

Product 1

HCID 70643(4-Methoxyphenyl)glyoxal

Procedure

Dimethylslufoxide (50 ml) solution of 4-methyoxyphenacylbromide (9.94 g, 43.4 mmol) and water (1.6 ml, 88.8 mmol) were stirred at 50° C. for 2.5 hr. Water was added and the solution was extracted with ethyl acetate 3 times and washed with brine and then dried over sodium sulfate. Removal of the solvent gave 4-methoxyphenylglyoxal (8.30 g, quant.).

Workup

  1. extractionthe solution was extracted with ethyl acetate 3 times
  2. washwashed with brine
  3. dry with materialdried over sodium sulfate
  4. customRemoval of the solvent

Sources & evidence

ORD record
ord-04d9b7cf628749039f767efa7fea906b
Source dataset
uspto-grants-2009_03
Patent number
US07504411B2

Reaction notes

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